Infectious Diseases Watch with Dr. Ed

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Infectious Diseases Watch with Dr. Ed

Edward J. Septimus, M.D., F.I.D.S.A, F.A.C.P, F.S.H.E.A.

Dr. Ed Septimus received his medical degree from Baylor College of Medicine in Houston in 1972. Dr. Septimus went on to complete his postgraduate training in internal medicine and infectious diseases at Baylor College of Medicine in Houston. Dr. Ed Septimus is board certified in both internal medicine and infectious diseases. He was VP Research and…

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General Infectious Diseases: Early Mobilization Mechanical Ventilation in ICU, AR in EU, Increase in Bsis with CRAB 2020 and 2021 in EU, Infection Prevention Staffing Levels and Hais, Global Mortality Associated with 33 Bacterial Pathogens in 2019, 5-Ethyl-2-Deoxyuridine K Pneumoniae Intracellular Killing, Clinical Impact of Ceftriaxone Resistance in E Coli BSI, Evaluation of Opt-Out Protocol for De-Escalation in Sepsis, Discontinuing MRSA And VRE Contact Precautions; Respiratory Viruses: Association Between Influenza Vaccination and Risk of Stroke, Influenza Vaccine to Reduce Adverse Vascular Events in Patients with Heart Failure, Influenza by the Numbers, Other Respiratory Viruses by the Numbers; Monkeypox: WHO Renames Monkeypox, Monkeypox by Numbers, Mutations in Virus Replication, Tecovirimat Resistance, Human Monkeypox in Women and Non-Binary Individuals, Effectiveness of One Dose of MVA-BN Smallpox Vaccine Against Monkeypox; COVID-19: Moderna Bivalent Booster, Pfizer Bivariant Against BQ.1.1, Covid by Numbers, Covid No Longer Mainly a Pandemic of the Unvaccinated, Changes in Population Immunity Against Infection and Severe Disease from Omicron Variants, Effectiveness of Bivalent Mrna Vaccines in Preventing Symptomatic Infection, Paxlovid Associated with Decreased Hospitalization Rate Among Adults, Prevalence of Contraindications to Nirmatrelvir-Ritonavir, Diagnostic Accuracy of Rapid Antigen Self-Tests in Asymptomatic Individuals, Covid and Excess All-Cause Mortality in the US and 20 Comparison Countries, Omicron Sublineage BQ.1.1 Resistance to Monoclonal Antibodies, Saliva Antibody-Fingerprint of Reactivated Viruses After Mild/Asymptomatic Covid, Vaccine Effectiveness Against Reinfection

November 28, 2022

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Safety and Efficacy of a Monoclonal Antibody Against Malaria in Mali, Routine Sterile Glove and Instrument Change at the Time of Abdominal Wound Closure to Prevent Surgical Site Infection, Comparative Safety and Health Care Expenditures Following Inappropriate Versus Appropriate OP Antibiotic URI, Viral Shedding 1 Year Following First-Episode Genital HSV-1 Infection, 2021 HAI Progress Report; Monkeypox: HHA Renews Public Health Emergency, Monkeypox by Numbers, Transmission Dynamics of MPXV in UK, Epidemiol and Clinical Features Children and Adolescents with MPXV, Global MPXV Hospitalization Rates; Influenza and RSV, Influenza Rates in US, RSV Rates in US; COVID-19: The Rise of BQ, Covid by Numbers, HHS Extend Health Emergency, Pfizer Bivalent Vaccine Study, EUA Anakinra, AAP Report, Hospitalizations Among US Infants, Variants to Watch, Safety Monitoring of Bivalent Vaccine Booster Persons ≥12 Years, Gut Microbiome Dysbiosis in Antibiotic Treated Patients with Bsis, Health Impairment in Children and Adolescents After Hospitalization with MIS-C, Comparative Risk Myocarditis/Pericarditis After Second Dose of Pfizer and Moderna, Protection Against Omicron from Vaccination and Previous Infection in Prison System, Fostamatinib for Treatment of Hospitalized Adults, VL Dynamics Delta and Omicron Variants Following Vaccination and Previous Infection, Nirmatrelvir and Risk of Post-Acute Sequelae, Translation Feasibility and Efficacy of Nasal Photodynamic Disinfection of SARS-Cov-2, Lifting Universal Masking in Schools, Acute and Postacute Sequelae Associated with Reinfection

November 14, 2022

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Diagnostic Accuracy of Bacterial and Viral Biomarker Point-of-Care Test in Outpatient Setting, Effectiveness of Ultraviolet-C Disinfection on Hospital-Onset Gram-Negative Rod Bloodstream Infection, Clinical Impact of Ceftriaxone Resistance in Escherichia Coli Bloodstream Infections, Changes in Burnout and Satisfaction with Work-Life Integration in Physicians During the First 2 Years of the COVID-19 Pandemic, Ebola: Uganda as Outbreak Grows to 100 Confirmed Cases; Fungal Report: WHO Fungal Priority Pathogens List to Guide Research, Development, and Public Health Action; Evolution of the Human Pathogenic Lifestyle in Fungi, Increased Deaths from Fungal Infections During the COVID-19 Pandemic, Pan-Cancer Mycobiome Analysis Reveals Fungal Involvement in Gastrointestinal and Lung Tumors; Respiratory Viruses: Tripledemic?, Vital Signs: Influenza Hospitalizations and Vaccination Coverage by Race and Ethnicity, Influenza and COVID-19 Vaccination Coverage Among Health Care Personnel; Monkeypox: Ocular Monkeypox, Infection Resulting from an Occupational Needlestick, Severe Monkeypox in Hospitalized Patients, Monkeypox by Numbers; COVID-19: FDA Authorizes Novavax as Booster for Adults, ACIP Support Adding Vaccines to Regular Immunizations, Variants BQ.1 and BQ.1.1, NIH COVID-19 Treatment Guidelines Panel’s Statement on Omicron Subvariants and Anti-SARS-CoV-2 Monoclonal Antibodies, Covid by Numbers, GAO Report: Maternal Health, Multicenter Comparison of Prevalence and Predictors of Antimicrobial Resistance in Hospitalized Patients Before and During Pandemic, Estimated Protection of Prior Infection Against Reinfection with the Omicron Variant Among Messenger RNA, Adverse Childhood Experiences During and Associations with Poor Mental Health and Suicidal Behaviors Among High School Students, Clinical Effectiveness and Safety of Remdesivir in Hemodialysis Patients with Covid, Association of mRNA Vaccination with Clinical and Virologic Features of Covid Among US Essential and Frontline Workers, Prevalence of Positive Rapid Antigen Tests After 7-Day Isolation Following Infection in College Athletes During Omicron Variant Predominance, Neutralization Escape by Omicron Subvariant BA.4.6, Effect of Ivermectin vs Placebo on Time to Sustained Recovery in Outpatients with Mild to Moderate Covid, Antibody Responses to Omicron BA.4/BA.5 Bivalent mRNA Vaccine Booster, Immunogenicity of the BA.5 Bivalent mRNA Vaccine Boosters, Recurrence of Symptoms Following a 2-Day Symptom Free Period in Patients with Covid

October 31, 2022

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General Infectious Diseases: FDA Pertussis Vaccine Approval, Outbreak Ebola Virus Central Uganda, Transmission of Carbapenem KP in US Hospitals, Correlation of Pyuria and Bacteriuria, Administration of a β-lactam Prior to Vancomycin; Influenza: 2022 National Survey: Attitudes about Influenza and Pneumococcal Disease and Impacts of Covid, US Flu Activity; Monkeypox: FDA EUA for New Monkeypox Test, Risk of Monkeypox Transmission to HCP, Epidemiological and Clinical Characteristics of Patients with Monkeypox, COVID: APIC Response to Lifting Universal Masking, Variant Updates, Covid by Numbers, XBB Variant, Evusheld Against BA.4.6, Commonwealth Analysis on Boosters, Preliminary on Pfizer Bivalent Vaccine, Novavax Booster, Pediatric Antibody Prevalence, FDA Approval Bivalent Boosters Ages 5-11; Clinical, Virologic, and Immunologic Evaluation Rebound Following Nirmatrelvir/Ritonavir, Diagnostic Accuracy of Rapid Antigen Tests with Unsupervised Self-Sampling, Clinical and Genetic Risk Factors VTE in Ambulatory Patients, Peripartum Outcomes Associated with Vaccination During Pregnancy, Impact of SARS-CoV-2 Vaccination and Boosters on Symptom Severity, Association Between Vaccination Status and Mortality Among Intubated Patients, Effectiveness and Durability of Pfizer Vaccine Against Hospitalization and ED Admissions, Severe Outcomes after Full Vaccination and Initial Booster, New Symptoms and Prevalence of Postacute Covid-19 Among Nonhospitalized Survivors, Molnupiravir Versus Usual Care in Early Treatment

October 17, 2022

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October 2, 2022

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Risk Factors and Clinical Outcomes Associated with Blood Culture Contamination, Evaluation of Hospital Blood Culture Utilization Rates to Identify Opportunities for Diagnostic Stewardship, Impact of Antimicrobial Stewardship Program on Hospital Acquired Candidemia, Association Between Time to Appropriate Antimicrobial Treatment and 30-day Mortality in Patients with Bloodstream Infections, Polio Declared State of Emergency for New York, Trends in Parents’ Confidence in Childhood Vaccines During Pandemic, Severe Respiratory Illnesses Associated with Rhinoviruses and/or Enteroviruses Including EV-D68 – Multistate, 2022; Monkeypox: Presenting as Proctitis in Men Who Have Sex with Men, Single and 2-dose Vaccinations with MVA-BN® Induce Durable B Cell Memory Responses in Healthy Volunteers Comparable to Older Generation Replicating Smallpox Vaccines, Two Cases of Monkeypox-Associated Encephalomyelitis, LA County Man Died from Monkeypox, Guidance for Tecovirimat Use Under Expanded Access Investigational New Drug Protocol during 2022 U.S. Outbreak, FDA Warns Monkeypox Virus May Develop Resistance to Tecovirimat, Case Trends in US, HIV and Sexually Transmitted Infections Among Persons With Monkeypox; COVID: Updates, The Lancet Commission on Lessons for Future Pandemic, Association Between BNT162b2 Vaccination and Reported Incidence of Post-COVID Symptoms: Cross-Sectional Study 2020-21, Israel, Mortality Risk Among Patients Hospitalized Primarily for COVID During Omicron and Delta Variant Pandemic Periods, Hospitalizations Among Vaccinated and Unvaccinated Adults 18 Years or Older in 13 US States, Resistance of SARS-Cov-2 Omicron Subvariant BA.4.6 to Antibody Neutralization, Effect of Test-and-Treat Approach to Vitamin D Supplementation on Risk of All Cause Acute Respiratory Tract Infection and COVID: Phase 3 Randomised Controlled Trial (CORONAVIT), Detection of Higher Cycle Threshold Values in Culturable SARS-Cov-2 Omicron BA.1 Sublineage Compared With Pre-Omicron Variant Specimens, Antibody from Single Human VH-Rearranging Mouse Neutralizes All SARS-Cov-2 Variants Through BA.5 by Inhibiting Membrane Fusion, Vaccines in Infants, Children, and Adolescents, Effectiveness and Durability of BNT162b2 Vaccine Against Omicron Sublineages in South Africa

September 18, 2022

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Ultra-Short-Course Antibiotics for Suspected Pneumonia With Preserved Oxygenation, Short-Course Antibiotic Therapy for Hospitalised Patients with Early Clinical Response in Community-Acquired Pneumonia: A Multicentre Cohort Study, Efficacy of Doxycycline for Mild-to-Moderate Community Acquired Pneumonia in Adults: A Systematic Review and Meta-analysis of Randomized Controlled Trials, Two-Day vs Seven-Day Course of Levofloxacin in Acute COPD Exacerbation: A Randomized Controlled Trial, CDCRreorganization; Monkeypox: FDA Alert Regarding Fecal Microbiota Transplants, Monkeypox by Numbers, High-Contact Object and Surface Contamination in a Household of Persons with Monkeypox Virus Infection — Utah, June 2022, Environmental Persistence of Monkeypox Virus on Surfaces in Household of Person with Travel-Associated Infection, Dallas, TX, Clinical Features and Novel Presentations of Human Monkeypox - London Centre; Covid-19: FDA Authorizes Emergency Use for Novavax for Ages 12-17; Moderna Sues Pfizer and BioNTech; Pfizer and Moderna Files for Emergency Use of BA.4/BA.5 Omicron Booster, Omicron Subvariant BA.2.75, Covid Hospitalization by Age, Covid by Numbers, Test-to-Stay (TTS) After SARS-CoV-2 Exposure: A Mitigation Strategy for Optionally Masked K-12 Schools, Durability of Heterologous and Homologous Vaccine Boosts, Randomized Trial of Metformin, Ivermectin, and Fluvoxamine, Oral Nirmatrelvir and Ritonavir in Non-Hospitalized Vaccinated Patients, Nirmatrelvir Use and Severe Outcomes During Omicron Surge, Real-World Effectiveness of Early Molnupiravir or Nirmatrelvir– Ritonavir in Hospitalised Patients Without Supplemental Oxygen, Requirement on Admission During Hong Kong’s Omicron BA.2 Wave: A Retrospective Cohort Study, Safety Monitoring of Pfizer-BioNTech Vaccine Booster Among Children Aged 5–11 Years — United States, May 17–July 31, 2022, Incubation Period Caused by Unique SARS-CoV-2 Strains A Systematic Review and Meta-Analysis, Risk for Myocardial Infarction, Stroke, and Pulmonary Embolism Following Vaccines in Adults Younger Than 75 Years in France

August 29, 2022

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Faecal microbiota transplantation reduces amounts of antibiotic resistance genes in patients with multidrug-resistant organisms; Multicenter Cohort Study of Ceftaroline versus Daptomycin for Treatment of Methicillin-Resistant Staphylococcus aureus Bloodstream Infection; US Considers Lengthening Gap Between First 2 COVID Shots to 8 Weeks; COVID-19 vaccine for kids under 5 delayed; FDA Authorizes New MCA, Bebtelovimab for Treatment of COVID-19; DSA Convalescent Plasma Guideline Update January 31, 2022; Vaccines Elicit Highly Conserved Cellular Immunity to SARS-CoV-2 Omicron; Gut microbiota dynamics in a prospective cohort of patients with post-acute COVID-19 syndrome; Association of SARS-CoV-2 Infection With Serious Maternal Morbidity and Mortality From Obstetric Complications; Characteristics, Outcomes, and Severity Risk Factors Associated With SARS- CoV-2 Infection Among Children in the US National COVID Cohort Collaborative; Durability of Anti-Spike Antibodies in Infants After Maternal COVID-19 Vaccination or Natural Infection; High Rates of Rapid Antigen Test Positivity After 5 days of Isolation for COVID-19; Initial analysis of viral dynamics and circulating viral variants during the mRNA- 1273 Phase 3 COVE trial; Protection against the Omicron Variant from Previous SARS-CoV-2 Infection; Waning 2-Dose and 3-Dose Effectiveness of mRNA Vaccines Against COVID-19– Associated Emergency Department and Urgent Care Encounters and Hospitalizations Among Adults During Periods of Delta and Omicron Variant Predominance — VISION Network, 10 States, August 2021–January 2022

February 14 2022

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