Infectious Diseases Watch with Dr. Ed

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Infectious Diseases Watch with Dr. Ed

Edward J. Septimus, M.D., F.I.D.S.A, F.A.C.P, F.S.H.E.A.

Dr. Ed Septimus received his medical degree from Baylor College of Medicine in Houston in 1972. Dr. Septimus went on to complete his postgraduate training in internal medicine and infectious diseases at Baylor College of Medicine in Houston. Dr. Ed Septimus is board certified in both internal medicine and infectious diseases. He was VP Research and…

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Clinicians of the Future-VII Editorial; Intravenous to Oral Antibiotic Switch Therapy Among Patients Hospitalized with Community-Acquired Pneumonia; Effects of Patient Beliefs Regarding the Need for Antibiotics and Prescribing Outcomes on Patient Satisfaction in Urgent-Care Settings, Sulbactam-durlobactam; Seres Therapeutics SEP-109 (Vowst); VE303, a Defined Bacterial Consortium, for Prevention of Recurrent Clostridioides difficile Infection A Randomized Clinical Trial; Fecal Microbiota Transplantation for the Treatment of Recurrent Clostridioides difficile (Clostridium difficile); Postexposure Doxycycline to Prevent Bacterial Sexually Transmitted Infections; STDs are on the Rise - New CDC Report; Epidemiology and Outcomes of Hospital-Acquired Bloodstream Infections in Intensive Care Unit Patients: the EUROBACT-2 International Cohort Study; Epidemiology, Resistance Profiles, and Outcomes of Bloodstream Infections in Community-Onset Sepsis in the United States; Incidence, Complications, and Costs of Peripheral Venous Catheter-Related Bacteraemia: A Retrospective, Single-Centre Study; Utility of Differential Time to Positivity in Diagnosing Central Line Associated Bloodstream Infections: A Systematic Review and Meta-Analysis; Efficacy and Safety of a Bivalent RSV Prefusion F Vaccine in Older Adults; Bivalent Prefusion F Vaccine in Pregnancy to Prevent RSV Illness in Infants; Reduced Respiratory Syncytial Virus Load, Symptoms, and Infections: A Human Challenge Trial of MVA-BN-RSV Vaccine; Increase in Pediatric Invasive Group A Streptococcus Infections(iGAS) — Colorado and Minnesota, October–December 2022; Worldwide Prevalence of Antibiotic-Associated Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis A Systematic Review and Meta-Analysis; European Centre for Disease Prevention and Control (ECDC) Released on COVID Vaccination; FDA and CDC Authorizes Changes to Simplify Use of Bivalent mRNA COVID-19 Vaccines; SARS-CoV-2 Neutralising Antibodies After Bivalent Versus Monovalent Booster; Durability of Bivalent Boosters Against Omicron Subvariants; Association of SARS-CoV-2 Vaccination or Infection with Bell Palsy A Systematic Review and Meta-Analysis; COVID-19 by the Numbers; Arcturus (formally, Omicron subvariant XBB.1.16) Now a VOI and XBB.1.9.1; Virological Characteristics of the SARS-CoV-2 Omicron XBB.1.16 variant; IDSA Guideline on the Treatment and Management of COVID-19 Update-Convalescent Plasma; The US FDA Gives an EUA for a New Monoclonal Antibody Treatment (vilobelimab); Optimal Duration of Systemic Corticosteroids in Coronavirus Disease 2019 Treatment: A Systematic Review and Meta-Analysis; Higher Dose Corticosteroids in Patients Admitted to Hospital With COVID-19 Who are Hypoxic but Not Requiring Ventilatory Support (RECOVERY): A Randomised, Controlled, Open-Label, Platform Trial; SARS-CoV-2 Variants and Multisystem Inflammatory Syndrome in Children; Risk of Death in Patients Hospitalized for COVID-19 vs Seasonal Influenza in Fall-Winter 2022-2023; SARS-CoV-2 During Omicron Variant Predominance Among Infants Born to People With SARS-CoV-2; Original Investigation | Pediatrics Assessment of Neurodevelopment in Infants With and Without Exposure to Asymptomatic or Mild Maternal SARS-CoV-2 Infection During Pregnancy; Maternal SARS-CoV-2, Placental Changes and Brain Injury in 2 Neonates; Sickness Presenteeism in Healthcare Workers During the Coronavirus Disease 2019 (COVID-19) Pandemic: An Observational Cohort Study; Association Between Stopping Universal SARS-CoV-2 Admission Testing and Hospital-Onset SARS-CoV-2 in England and Scotland; Universal Masking in Health Care Settings: A Pandemic Strategy Whose Time Has Come and Gone, For Now

May 2023

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Nipah Outbreak in Bangladesh; Marburg Virus Equatorial Guinea; Effect of Antibiotic Prescription Audit and Feedback on Antibiotic Prescribing in Primary Care; COVID-19 and Outpatient Antibiotic Prescriptions in the United States, Antimicrobial for 7 or 14 Days for Febrile Urinary Tract Infection in Men, A Multicenter Noninferiority Double Blind Placebo-Controlled, Randomized Clinical Trial; How Climate Change is Spreading Malaria in Africa; Rapid Range Shifts in African Anopheles Mosquitoes Over the Last Century; Real-World Use of Bezlotoxumab and Fecal Microbiota Transplantation for the Treatment of Clostridioides difficile Infection; Safety and Tolerability of SER-109 as an Investigational Microbiome Therapeutic in Adults With Recurrent Clostridioides difficile Infection: A Phase 3, Open-Label, Single-Arm Trial; Screening for Clostridioides difficile Colonization at Admission to the Hospital; The Impact of Timing of Infectious Disease Consultation for Staphylococcus Aureus Bacteremia; Health Disparities in Hemodialysis-Associated Staphylococcus Aureus Bloodstream Infections; People-Centred Framework for Addressing Antimicrobial Resistance in the Human Health Sector; Association of Proton Pump Inhibitor Use with Risk of Acquiring Drug-Resistant Enterobacterales; Increase in Extensively Drug-Resistant Shigellosis; Mpox in People with Advanced HIV Infection; CDC Panel Recommends Jynneos Vaccine for All Adults at Risk; Screening and Testing for Hepatitis B Virus Infection: CDC Recommendations; Household Transmission of Influenza A Viruses in 2021-2022; Respiratory Syncytial Virus Disease Burden in Community-Dwelling and Long-Term Care Facility Older Adults in Europe and the United States; FDA Advisors Recommend First-Ever RSV Vaccines for Adults; Physical Interventions to Interrupt or Reduce the Spread of Respiratory Viruses; First At-Home Combination Test for Flu and Covid-19; Covid-19 Impact: Three Year Anniversary; Lab Leak Most Likely Origin of Covid-19 Pandemic; Wastewater-Based Monitoring of SARS-Cov-2 at UK Airports and Its Potential Role in International Public Health Surveillance; Aircraft Wastewater Surveillance for Early Detection of SARS-Cov-2 Variants — JFK International Airport; Effect of Predeparture Testing on Postarrival SARS-Cov-2–Positive Test Results Among International Travelers — CDC Traveler-Based Genomic Surveillance Program; Viral Burden Rebound in Hospitalised Patients With COVID-19 Receiving Oral Antivirals in Hong Kong; Association of COVID-19 Vaccination with Risk for Incident Diabetes After COVID-19 Infection; Past SARS-Cov-2 Infection Protection Against Re-Infection; Rethinking Next-Generation Vaccines for Coronaviruses, Influenza Viruses, and Other Respiratory Viruses; Assessment of COVID-19 as the Underlying Cause of Death Among Children and Young People Aged 0 To 19 Years in the US; Hospital Outcomes of Community-Acquired SARS-Cov-2 Omicron Variant Infection Compared with Influenza Infection in Switzerland; Symptom and Viral Rebound in Untreated SARS-Cov-2 Infection; Impact of Vaccination on Major Adverse Cardiovascular Events in Patients With COVID-19 Infection; Effectiveness of Bivalent Mrna Booster Vaccination Against SARS-Cov-2 Omicron Infection; Bivalent Booster Effectiveness Against Severe COVID-19 2 Outcomes; Effects of Remdesivir in Patients Hospitalised With COVID-19

March 2023

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Physician 2022 Burnout Rates, Piperacillin Nephrotoxicity is Driven by Elevated Serum Trough Concentrations, Going Back in Time: Increasing Penicillin Susceptibility Among Methicillin-Susceptible Staphylococcus Aureus Osteoarticular Infections in Children, Probiotic for Pathogen-Specific Staphylococcus Aureus Decolonisation in Thailand, FDA Panel Recommends Rezafungin as New Candida Treatment, 2 Days vs. 5 Days of Postoperative Antibiotics for Complex Appendicitis, Multicentre, Noninferiority Randomised Trial, Norovirus National Trends, Outbreak of Extensively Drug-Resistant Pseudomonas Aeruginosa Associated With Artificial Tears, Comparing Complication Rates of Midline Catheter vs. Peripherally Inserted Central Catheter (PICC), High Dose Cefepime vs. Carbapenems for Bacteremia Caused by Enterobacterales With Moderate to High Risk of Clinically Significant Ampc Β-Lactamase Production, Azithromycin to Prevent Sepsis or Death in Women Planning a Vaginal Birth, Worst Avian Flu in U.S. History Is Hitting Poultry, Wild Birds, Even Bears, Bird Flu Has Begun to Spread in Mammals, Codetections of Other Respiratory Viruses Among Children Hospitalized With COVID-19, A Pragmatic Randomized Feasibility Trial of Influenza Vaccines, HHS Weekly Report (Influenza/RSV), The Influence of Rapid Influenza Diagnostic Testing on Clinician Decision-Making for Patients With Acute Respiratory Infection in Urgent Care, Sensitivity of RIDTs for Influenza, US Plans to End Public Health Emergency for Covid-19 in May, Covid-19 by the Numbers, FDA Removes Positive COVID-19 Test Requirement for Antiviral Treatments, Available Outpatient Covid-19 Treatments, Information for Persons Who are Immunocompromised Regarding Prevention and Treatment of SARS-Cov-2 Infection in the Context of Currently Circulating Omicron Sublineages, FDA Withdraws EUA for Tixagevimab/Cilgavimab, IDSA Updated Guideline for COVID-19, Early Treatment With Pegylated Interferon Lambda for Covid-19, Children and COVID: Weekly Cases, Assessment of Efficacy and Safety of Mrna COVID-19 Vaccines in Children Aged 5 to 11 Years, Adverse Events Following the BNT162b2 Mrna COVID-19 Vaccine (Pfizer-Biontech) in Aotearoa New Zealand, Novavax NVX COV2373 Triggers Neutralization of Omicron Sub Lineages, Early Estimates of Bivalent Mrna Booster Dose Vaccine Effectiveness in Preventing Symptomatic SARS-Cov-2 Infection Attributable to Omicron BA.5– And XBB/XBB.1.5–Related Sublineages Among Immunocompetent Adults — Increasing Community Access to Testing Program, COVID-19 Incidence and Mortality Among Unvaccinated And Vaccinated Persons Aged ≥12 Years by Receipt of Bivalent Booster Doses and Time Since Vaccination, Protective Effectiveness of Previous SARS-Cov-2 Infection and Hybrid Immunity Against the Omicron Variant and Severe Disease

February 2023

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Efficacy and Safety of Azithromycin vs Placebo to Treat Lower Respiratory Tract Infections Associated with Low Procalcitonin; Association of Appropriate Empirical Antimicrobial Therapy with In-Hospital Mortality in Patients with Bloodstream Infections; Antimicrobial Resistance and Mortality Following E. Coli Bacteremia; Antibiotic Use as a Risk Factor for Inflammatory Bowel Disease; Machine Learning to Stratify Methicillin-Resistant Staphylococcus Aureus Risk Among Hospitalized Patients with Community-Acquired Pneumonia; Defining Optimal Duration of Therapy for Hospitalized Patients with Complicated Urinary Tract Infections and Associated Bacteremia; Risk Factors Associated with Antimicrobial Resistance and Adverse Short-Term Health Outcomes Among Adult and Adolescent Female Outpatients with Uncomplicated UTI; Association of Pneumococcal Conjugate Vaccine Use with Hospitalized Pneumonia in Medicare Beneficiaries 65 Years or Older; Proposed HHS National Action Plan; Antibiotic Concentrations and Antibiotic Resistance in Aquatic Environments of the WHO Western Pacific and South-East Asia Regions; Uganda’s Ebola Outbreak; FDA OKs Tdap Shot in Pregnancy to Protect Newborns from Pertussis; Vaccination Coverage with Selected Vaccines and Exemption Rates Among Children in Kindergarten; Moderna Reports RSV Vaccine Cuts Risk of Respiratory Diseases in Older Adults; The Young Were Not Spared: What Death Certificates Reveal About Non-Covid Excess Deaths; Commentary: Covid-19 Year 4; Are Americans Dying from Covid-19 or with Covid-19?; WHO’s Updated Covid Guidelines; US Renews Health Emergency; NIH Updates Regarding Use of Bebtelovimab; CDC & FDA Identify Preliminary Covid Vaccine Safety Signal for Persons Aged 65 Years and Older; Combined IDSA/SHEA Statement: U.S. Must Consider Broader Measures to Mitigate COVID-19 Transmission; Covid by Numbers; Infectiousness of SARS-Cov-2 Breakthrough Infections and Reinfections During Omicron Wave; Protection Against Symptomatic Infection with Delta and Omicron BA.1 and BA.2 SARS-Cov-2 Variants After Previous Infection and Vaccination in Adolescents; Enhanced Transmissibility of XBB.1.5 is Contributed by Both Strong ACE2 Binding and Antibody Evasion; Neutralisation Sensitivity of the SARS-Cov-2 XBB.1 Lineage; COVID-19 Convalescent Plasma for Treatment of Immunocompromised Patients; Effectiveness of Bivalent mRNA Vaccine in Preventing Severe Covid Outcomes; Impaired CD4+ T Cell Response in Older Adults is Associated with Reduced Immunogenicity and Reactogenicity of mRNA Vaccination; Outcomes Among Mechanically Ventilated Patients with Severe Pneumonia and Acute Hypoxemic Respiratory Failure from SARS-Cov-2 and Other Etiologies; Long Covid Outcomes at One Year After Mild SARS-Cov-2 Infection; Long COVID: Major Findings, Mechanisms and Recommendations

January 23, 2023

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General Infectious Diseases: Shortage of Infectious Disease Physicians, Impact of Rapid Molecular Test for Klebsiella pneumoniae Carbapenemase and Ceftazidime-Avibactam Use on Outcomes After Bacteremia Caused by Carbapenem–Resistant Enterobacterales, Case-Control Study Evaluating Unnecessary Use of Intravenous Broad-Spectrum Antibiotics in Presumed Sepsis and Septic-Shock Patients, Association of Follow-Up Blood Cultures with Mortality in Patients with Gram-Negative Bloodstream Infections a Systematic Review and Meta-Analysis, Increase in Pediatric Invasive Group A Streptococcal Infections, Association of Adverse Events with Antibiotic Treatment for Urinary Tract Infection; Mpox: Surveillance, Case Investigation and Contact Tracing for Monkeypox: Interim Guidance, Mpox by Numbers, Clinical Features and Management of Individuals Admitted Hospital with Monkeypox and Associated Complications Across the UK; Respiratory Viruses (Not SARS-Cov-2): Prevalence of SARS-Cov-2 and Influenza Coinfection and Clinical Characteristics Among Children and Adolescent Aged, Influenza Vaccine Effectiveness Against Influenza A(H3N2)- Related Illness in United States During 2021–2022 Influenza Season, Respiratory Viruses by Numbers; COVID-19: Covid-19 Risk Continuum, US Offers Free At-Home Tests Again, US to Require Negative Tests for Travelers Coming from China, IDSA Update on Antigen Testing, Covid-19 by Numbers, Association of Time to Surgery After Infection with Risk of Postoperative Cardiovascular Morbidity, Asymptomatic Screening for Severe Acute Respiratory Coronavirus Virus 2 (SARS-Cov-2) as an Infection Prevention Measure in Healthcare Facilities: Challenges and Considerations, SARS-Cov-2 Infection History and Antibody Response to Three Mrna Vaccine, Molnupiravir Plus Usual Care Versus Usual Care Alone as Early Treatment for Adults with COVID at Increased Risk of Adverse Outcomes (PANORAMIC): An Open-Label, Platform Adaptive Randomised Controlled Trial, VV116 Versus Nirmatrelvir–Ritonavir for Oral Treatment, High Titers of Infectious SARS-Cov-2 in COVID Corpses, Postmortem Stability of SARS-Cov-2 in Nasopharyngeal Mucosa, Infectivity of Deceased COVID Patients, SARS-Cov-2 Infection and Persistence in Human Body and Brain at Autopsy, Council of State and Territorial Epidemiologists/CDC Surveillance Case Definition for Multisystem Inflammatory Syndrome in Children Associated with SARS-Cov-2 Infection, Alarming Antibody Evasion Properties of Rising SARS-Cov-2 BQ and XBB Subvariants, Early Estimates of Bivalent Mrna Vaccine Effectiveness in Preventing COVID – Associated Emergency Department or Urgent Care Encounters and Hospitalizations Among Immunocompetent Adults, Early Estimates of Bivalent Mrna Vaccine Effectiveness in Preventing COVID – Associated Hospitalization Among Immunocompetent Adults Aged ≥65 Years, Predictors of Severe Acute Respiratory Syndrome Coronavirus 2 Infection Following High-Risk Exposure, Impact of SARS-Cov-2 Variants on Inpatient Clinical Outcome, Outcomes and Adverse Effects of Baricitinib Versus Tocilizumab in the Management of Severe COVID

January 1, 2023

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General Infectious Diseases: Anti-Anaerobic Antibiotics Increase Risk of Adverse Clinical Outcomes In Critically Ill Patients, Effect of Selective Decontamination of Digestive Tract on Hospital Mortality in Critically Ill Patients Receiving Mechanical Ventilation, Association Between Selective Decontamination of Digestive Tract and In-Hospital Mortality in Intensive Care Unit Patients Receiving Mechanical Ventilation, FDA OKs First Fecal Transplant Therapy for Recurrent C Difficile, Efficacy and Safety of RBX2660 in PUNCH CD3, a Phase III, Randomized, Double Blind, Placebo Controlled Trial, Progress Toward Regional Measles Elimination, Respiratory Viruses: RSV by Numbers, Influenza by Numbers, VE of Influenza Vaccination of Pregnant for Prevention of Maternal and Early Infant Hospitalizations in South Africa, A Multivalent Nucleoside-Modified Mrna Vaccine Against All Known Influenza Virus Subtypes, Mpox: Mpox by Numbers, Single and 2-Dose Vaccinations with Modified Vaccinia Ankara-Bavarian Nordic® Induce Durable B Cell Memory Responses, Reduced Risk for Mpox After Receipt of 1 or 2 Doses of JYNNEOS Vaccine Compared with Risk of Unvaccinated, COVID-19: FDA Authorizes Updated Covid Vaccines for Children as Young As 6 Months, Here We Go Again and Covid by Numbers, Bebtelovimab Update, Association of COVID with Diabetes: A Systematic Review and Meta Analysis, Free Fatty Acid–Binding Pocket is a Conserved Hallmark in Pathogenic Β-Coronavirus Spike Proteins from SARS-Cov to Omicron, Shifting Mortality Dynamics in US During Covid Pandemic as Measured by Years of Life Lost, Medical Masks vs N95 Respirators for Preventing Covid Among Health Care Workers, Association of Initial SARS-Cov-2 Test Positivity with Patient-Reported Well-Being 3 Months After Symptomatic Illness, VE of Mrna-1273, BNT162b2, and BBIBP-Corv Vaccines Against Infection and Mortality in Children in Argentina, SARS-Cov-2 Viral Load and Shedding Kinetics, Low Neutralization of SARS-Cov-2 Omicron BA.2.75.2, BQ.1.1, and XBB.1 by Parental Mrna Vaccine or a BA.5-Bivalent Booster, Efficacy of Antiviral Agents Against Omicron Subvariants BQ.1.1 and XBB, Twice-Daily Oral Zinc in Treatment of Patients with Coronavirus Disease 2019: A Randomized Double-Blind Controlled Trial

December 12, 2022

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General Infectious Diseases: Early Mobilization Mechanical Ventilation in ICU, AR in EU, Increase in Bsis with CRAB 2020 and 2021 in EU, Infection Prevention Staffing Levels and Hais, Global Mortality Associated with 33 Bacterial Pathogens in 2019, 5-Ethyl-2-Deoxyuridine K Pneumoniae Intracellular Killing, Clinical Impact of Ceftriaxone Resistance in E Coli BSI, Evaluation of Opt-Out Protocol for De-Escalation in Sepsis, Discontinuing MRSA And VRE Contact Precautions; Respiratory Viruses: Association Between Influenza Vaccination and Risk of Stroke, Influenza Vaccine to Reduce Adverse Vascular Events in Patients with Heart Failure, Influenza by the Numbers, Other Respiratory Viruses by the Numbers; Monkeypox: WHO Renames Monkeypox, Monkeypox by Numbers, Mutations in Virus Replication, Tecovirimat Resistance, Human Monkeypox in Women and Non-Binary Individuals, Effectiveness of One Dose of MVA-BN Smallpox Vaccine Against Monkeypox; COVID-19: Moderna Bivalent Booster, Pfizer Bivariant Against BQ.1.1, Covid by Numbers, Covid No Longer Mainly a Pandemic of the Unvaccinated, Changes in Population Immunity Against Infection and Severe Disease from Omicron Variants, Effectiveness of Bivalent Mrna Vaccines in Preventing Symptomatic Infection, Paxlovid Associated with Decreased Hospitalization Rate Among Adults, Prevalence of Contraindications to Nirmatrelvir-Ritonavir, Diagnostic Accuracy of Rapid Antigen Self-Tests in Asymptomatic Individuals, Covid and Excess All-Cause Mortality in the US and 20 Comparison Countries, Omicron Sublineage BQ.1.1 Resistance to Monoclonal Antibodies, Saliva Antibody-Fingerprint of Reactivated Viruses After Mild/Asymptomatic Covid, Vaccine Effectiveness Against Reinfection

November 28, 2022

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Safety and Efficacy of a Monoclonal Antibody Against Malaria in Mali, Routine Sterile Glove and Instrument Change at the Time of Abdominal Wound Closure to Prevent Surgical Site Infection, Comparative Safety and Health Care Expenditures Following Inappropriate Versus Appropriate OP Antibiotic URI, Viral Shedding 1 Year Following First-Episode Genital HSV-1 Infection, 2021 HAI Progress Report; Monkeypox: HHA Renews Public Health Emergency, Monkeypox by Numbers, Transmission Dynamics of MPXV in UK, Epidemiol and Clinical Features Children and Adolescents with MPXV, Global MPXV Hospitalization Rates; Influenza and RSV, Influenza Rates in US, RSV Rates in US; COVID-19: The Rise of BQ, Covid by Numbers, HHS Extend Health Emergency, Pfizer Bivalent Vaccine Study, EUA Anakinra, AAP Report, Hospitalizations Among US Infants, Variants to Watch, Safety Monitoring of Bivalent Vaccine Booster Persons ≥12 Years, Gut Microbiome Dysbiosis in Antibiotic Treated Patients with Bsis, Health Impairment in Children and Adolescents After Hospitalization with MIS-C, Comparative Risk Myocarditis/Pericarditis After Second Dose of Pfizer and Moderna, Protection Against Omicron from Vaccination and Previous Infection in Prison System, Fostamatinib for Treatment of Hospitalized Adults, VL Dynamics Delta and Omicron Variants Following Vaccination and Previous Infection, Nirmatrelvir and Risk of Post-Acute Sequelae, Translation Feasibility and Efficacy of Nasal Photodynamic Disinfection of SARS-Cov-2, Lifting Universal Masking in Schools, Acute and Postacute Sequelae Associated with Reinfection

November 14, 2022

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Diagnostic Accuracy of Bacterial and Viral Biomarker Point-of-Care Test in Outpatient Setting, Effectiveness of Ultraviolet-C Disinfection on Hospital-Onset Gram-Negative Rod Bloodstream Infection, Clinical Impact of Ceftriaxone Resistance in Escherichia Coli Bloodstream Infections, Changes in Burnout and Satisfaction with Work-Life Integration in Physicians During the First 2 Years of the COVID-19 Pandemic, Ebola: Uganda as Outbreak Grows to 100 Confirmed Cases; Fungal Report: WHO Fungal Priority Pathogens List to Guide Research, Development, and Public Health Action; Evolution of the Human Pathogenic Lifestyle in Fungi, Increased Deaths from Fungal Infections During the COVID-19 Pandemic, Pan-Cancer Mycobiome Analysis Reveals Fungal Involvement in Gastrointestinal and Lung Tumors; Respiratory Viruses: Tripledemic?, Vital Signs: Influenza Hospitalizations and Vaccination Coverage by Race and Ethnicity, Influenza and COVID-19 Vaccination Coverage Among Health Care Personnel; Monkeypox: Ocular Monkeypox, Infection Resulting from an Occupational Needlestick, Severe Monkeypox in Hospitalized Patients, Monkeypox by Numbers; COVID-19: FDA Authorizes Novavax as Booster for Adults, ACIP Support Adding Vaccines to Regular Immunizations, Variants BQ.1 and BQ.1.1, NIH COVID-19 Treatment Guidelines Panel’s Statement on Omicron Subvariants and Anti-SARS-CoV-2 Monoclonal Antibodies, Covid by Numbers, GAO Report: Maternal Health, Multicenter Comparison of Prevalence and Predictors of Antimicrobial Resistance in Hospitalized Patients Before and During Pandemic, Estimated Protection of Prior Infection Against Reinfection with the Omicron Variant Among Messenger RNA, Adverse Childhood Experiences During and Associations with Poor Mental Health and Suicidal Behaviors Among High School Students, Clinical Effectiveness and Safety of Remdesivir in Hemodialysis Patients with Covid, Association of mRNA Vaccination with Clinical and Virologic Features of Covid Among US Essential and Frontline Workers, Prevalence of Positive Rapid Antigen Tests After 7-Day Isolation Following Infection in College Athletes During Omicron Variant Predominance, Neutralization Escape by Omicron Subvariant BA.4.6, Effect of Ivermectin vs Placebo on Time to Sustained Recovery in Outpatients with Mild to Moderate Covid, Antibody Responses to Omicron BA.4/BA.5 Bivalent mRNA Vaccine Booster, Immunogenicity of the BA.5 Bivalent mRNA Vaccine Boosters, Recurrence of Symptoms Following a 2-Day Symptom Free Period in Patients with Covid

October 31, 2022

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General Infectious Diseases: FDA Pertussis Vaccine Approval, Outbreak Ebola Virus Central Uganda, Transmission of Carbapenem KP in US Hospitals, Correlation of Pyuria and Bacteriuria, Administration of a β-lactam Prior to Vancomycin; Influenza: 2022 National Survey: Attitudes about Influenza and Pneumococcal Disease and Impacts of Covid, US Flu Activity; Monkeypox: FDA EUA for New Monkeypox Test, Risk of Monkeypox Transmission to HCP, Epidemiological and Clinical Characteristics of Patients with Monkeypox, COVID: APIC Response to Lifting Universal Masking, Variant Updates, Covid by Numbers, XBB Variant, Evusheld Against BA.4.6, Commonwealth Analysis on Boosters, Preliminary on Pfizer Bivalent Vaccine, Novavax Booster, Pediatric Antibody Prevalence, FDA Approval Bivalent Boosters Ages 5-11; Clinical, Virologic, and Immunologic Evaluation Rebound Following Nirmatrelvir/Ritonavir, Diagnostic Accuracy of Rapid Antigen Tests with Unsupervised Self-Sampling, Clinical and Genetic Risk Factors VTE in Ambulatory Patients, Peripartum Outcomes Associated with Vaccination During Pregnancy, Impact of SARS-CoV-2 Vaccination and Boosters on Symptom Severity, Association Between Vaccination Status and Mortality Among Intubated Patients, Effectiveness and Durability of Pfizer Vaccine Against Hospitalization and ED Admissions, Severe Outcomes after Full Vaccination and Initial Booster, New Symptoms and Prevalence of Postacute Covid-19 Among Nonhospitalized Survivors, Molnupiravir Versus Usual Care in Early Treatment

October 17, 2022

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October 2, 2022

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Risk Factors and Clinical Outcomes Associated with Blood Culture Contamination, Evaluation of Hospital Blood Culture Utilization Rates to Identify Opportunities for Diagnostic Stewardship, Impact of Antimicrobial Stewardship Program on Hospital Acquired Candidemia, Association Between Time to Appropriate Antimicrobial Treatment and 30-day Mortality in Patients with Bloodstream Infections, Polio Declared State of Emergency for New York, Trends in Parents’ Confidence in Childhood Vaccines During Pandemic, Severe Respiratory Illnesses Associated with Rhinoviruses and/or Enteroviruses Including EV-D68 – Multistate, 2022; Monkeypox: Presenting as Proctitis in Men Who Have Sex with Men, Single and 2-dose Vaccinations with MVA-BN® Induce Durable B Cell Memory Responses in Healthy Volunteers Comparable to Older Generation Replicating Smallpox Vaccines, Two Cases of Monkeypox-Associated Encephalomyelitis, LA County Man Died from Monkeypox, Guidance for Tecovirimat Use Under Expanded Access Investigational New Drug Protocol during 2022 U.S. Outbreak, FDA Warns Monkeypox Virus May Develop Resistance to Tecovirimat, Case Trends in US, HIV and Sexually Transmitted Infections Among Persons With Monkeypox; COVID: Updates, The Lancet Commission on Lessons for Future Pandemic, Association Between BNT162b2 Vaccination and Reported Incidence of Post-COVID Symptoms: Cross-Sectional Study 2020-21, Israel, Mortality Risk Among Patients Hospitalized Primarily for COVID During Omicron and Delta Variant Pandemic Periods, Hospitalizations Among Vaccinated and Unvaccinated Adults 18 Years or Older in 13 US States, Resistance of SARS-Cov-2 Omicron Subvariant BA.4.6 to Antibody Neutralization, Effect of Test-and-Treat Approach to Vitamin D Supplementation on Risk of All Cause Acute Respiratory Tract Infection and COVID: Phase 3 Randomised Controlled Trial (CORONAVIT), Detection of Higher Cycle Threshold Values in Culturable SARS-Cov-2 Omicron BA.1 Sublineage Compared With Pre-Omicron Variant Specimens, Antibody from Single Human VH-Rearranging Mouse Neutralizes All SARS-Cov-2 Variants Through BA.5 by Inhibiting Membrane Fusion, Vaccines in Infants, Children, and Adolescents, Effectiveness and Durability of BNT162b2 Vaccine Against Omicron Sublineages in South Africa

September 18, 2022

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Ultra-Short-Course Antibiotics for Suspected Pneumonia With Preserved Oxygenation, Short-Course Antibiotic Therapy for Hospitalised Patients with Early Clinical Response in Community-Acquired Pneumonia: A Multicentre Cohort Study, Efficacy of Doxycycline for Mild-to-Moderate Community Acquired Pneumonia in Adults: A Systematic Review and Meta-analysis of Randomized Controlled Trials, Two-Day vs Seven-Day Course of Levofloxacin in Acute COPD Exacerbation: A Randomized Controlled Trial, CDCRreorganization; Monkeypox: FDA Alert Regarding Fecal Microbiota Transplants, Monkeypox by Numbers, High-Contact Object and Surface Contamination in a Household of Persons with Monkeypox Virus Infection — Utah, June 2022, Environmental Persistence of Monkeypox Virus on Surfaces in Household of Person with Travel-Associated Infection, Dallas, TX, Clinical Features and Novel Presentations of Human Monkeypox - London Centre; Covid-19: FDA Authorizes Emergency Use for Novavax for Ages 12-17; Moderna Sues Pfizer and BioNTech; Pfizer and Moderna Files for Emergency Use of BA.4/BA.5 Omicron Booster, Omicron Subvariant BA.2.75, Covid Hospitalization by Age, Covid by Numbers, Test-to-Stay (TTS) After SARS-CoV-2 Exposure: A Mitigation Strategy for Optionally Masked K-12 Schools, Durability of Heterologous and Homologous Vaccine Boosts, Randomized Trial of Metformin, Ivermectin, and Fluvoxamine, Oral Nirmatrelvir and Ritonavir in Non-Hospitalized Vaccinated Patients, Nirmatrelvir Use and Severe Outcomes During Omicron Surge, Real-World Effectiveness of Early Molnupiravir or Nirmatrelvir– Ritonavir in Hospitalised Patients Without Supplemental Oxygen, Requirement on Admission During Hong Kong’s Omicron BA.2 Wave: A Retrospective Cohort Study, Safety Monitoring of Pfizer-BioNTech Vaccine Booster Among Children Aged 5–11 Years — United States, May 17–July 31, 2022, Incubation Period Caused by Unique SARS-CoV-2 Strains A Systematic Review and Meta-Analysis, Risk for Myocardial Infarction, Stroke, and Pulmonary Embolism Following Vaccines in Adults Younger Than 75 Years in France

August 29, 2022

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Faecal microbiota transplantation reduces amounts of antibiotic resistance genes in patients with multidrug-resistant organisms; Multicenter Cohort Study of Ceftaroline versus Daptomycin for Treatment of Methicillin-Resistant Staphylococcus aureus Bloodstream Infection; US Considers Lengthening Gap Between First 2 COVID Shots to 8 Weeks; COVID-19 vaccine for kids under 5 delayed; FDA Authorizes New MCA, Bebtelovimab for Treatment of COVID-19; DSA Convalescent Plasma Guideline Update January 31, 2022; Vaccines Elicit Highly Conserved Cellular Immunity to SARS-CoV-2 Omicron; Gut microbiota dynamics in a prospective cohort of patients with post-acute COVID-19 syndrome; Association of SARS-CoV-2 Infection With Serious Maternal Morbidity and Mortality From Obstetric Complications; Characteristics, Outcomes, and Severity Risk Factors Associated With SARS- CoV-2 Infection Among Children in the US National COVID Cohort Collaborative; Durability of Anti-Spike Antibodies in Infants After Maternal COVID-19 Vaccination or Natural Infection; High Rates of Rapid Antigen Test Positivity After 5 days of Isolation for COVID-19; Initial analysis of viral dynamics and circulating viral variants during the mRNA- 1273 Phase 3 COVE trial; Protection against the Omicron Variant from Previous SARS-CoV-2 Infection; Waning 2-Dose and 3-Dose Effectiveness of mRNA Vaccines Against COVID-19– Associated Emergency Department and Urgent Care Encounters and Hospitalizations Among Adults During Periods of Delta and Omicron Variant Predominance — VISION Network, 10 States, August 2021–January 2022

February 14 2022

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