GCC Shared Core Facilities

The Combinatorial Drug Discovery Program (CDDP) located within the Texas A&M Institute of Biosciences and Technology in Houston, TX is a CPRIT-funded drug discovery core facility. The core offers industry standard automated high throughput library screening and imaging services to all investigators from academic institutions and both non-profit and for-profit entities. The CDDP can run large traditional high throughput small molecule screens for early lead or probe development or small and focused screens supporting lead optimization and structure activity relationship screens. The core maintains and makes available more than 20 collections of drugs approved for the use in humans for repurposing studies and of small molecules, bioactive compounds, and natural products for probe identification and mechanism of action studies. The CDDP operates a unique drug combination screening platform often repurposing approved drugs and investigational agents that can be rapidly advanced to pre-clinical or clinical trials thus greatly reducing drug development time. The CDDP team has full-time screening experts with both industry and academic drug discovery research experience. The screening team can assist with assay design, development, and optimization moving bench assays to automation platforms for higher throughput. Our research team also includes experts in the development and implementation of both conventional statistical and advanced machine learning and neural network analysis models that are applied to the extraction and interpretation of high throughput chemical screening data. With additional experimental data from our collaborators, the CDDP can add value to the screening results we generate by providing secondary biostatistics, pharmacogenomic, pathway, and machine learning analyses. The CDDP is a complete resource that supports all stages of the drug discovery and development pipeline where high throughput screening methods are employed. For more information, contact Core Director Clifford Stephan.

Looking for a particular piece of equipment?

Did you know that the GCC has a Shared Equipment and Resource Committee (SERC) composed of the Directors/Leaders in equipment inventory and acquisition from each of the GCC institutions?  If you are looking for a particular piece of equipment, please email Suzanne Tomlinson, and the committee members will work together to try to locate it and introduce you to the PI who owns/administers it.