Small Molecules for Research and Medicine: The overall goal of the GCC CG has been to embed within each of the GCC institutions the capability of supporting high throughput and high content screening research projects through an integrated program of specialized equipment and expertise that would be available to individual researchers and research groups. Our strategy has always been to tailor our organization and its operations to match the priorities and the unique capabilities of an academic research center and to build upon the framework of inter-institutional collaboration embodied in the GCC. In addition, the Chemical Genomics Consortium has established a Central High-throughput Screening Laboratory capable of serving as a Core Lab to support large screens for researchers from all the GCC institutions. A special emphasis of the Chemical Genomics Consortium has been on the development of a specialized capability in the application of cell-based imaging technologies to chemical genomics research. As an academic research program, we are interested in exploring how these new technologies can be applied to “non-traditional” targets and to complex biological processes to develop new tools to probe the function of the genome. John S. Dunn, GCC for Chemical Genomics Member Institutions Baylor College of Medicine Rice University Texas Southern University Houston Methodist Research Institute University of Houston The University of Texas Health Science Center at Houston The University of Texas Medical Branch at Galveston The University of Texas M. D. Anderson Cancer Center The Institute of Biosciences and Technology of Texas A&M Health Science Center.